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June 2012

Rana P, Anson B, Engle S, and Will Y

Characterization of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

Toxicol Sci 130(1):117-31

Publication Date: June 27, 2012

Product Type: iCell Cardiomyocytes

Summary:

Analysis of iCell Cardiomyocytes bioenergetics function revealed that iCell Cardiomyocytes can utilize a variety of energy substrates and exhibit expected responses to known mitochondrial toxicants.

Impact:

iCell Cardiomyocytes were shown to exhibit appropriate bioenergetics functions and can be used to detect mitochondrial dysfunction, which is an important mechanism of drug-induced cardiotoxicity.

Zhi D, Irvin MR, Gu CC, Stoddard AJ, Lorier R, Matter A, Rao DC, Srinivasasainagendra V, Tiwari HK, Turner A, Broeckel U, and Arnett DK

Whole-exome Sequencing and an iPSC-derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy

Front Genet 3:92

Publication Date: June 2, 2012

Product Type: iCell Cardiomyocytes

Summary:

iCell Cardiomyocytes were used to develop a functional cellular model of left ventricular hypertrophy (LVH), which enabled the identification of novel disease-associated genetic polymorphisms from a donor population.

Impact:

iCell Cardiomyocytes were used to develop an in vitro cellular model that exhibits functional characteristics of the human cardiac disease LVH. This model was used to identify novel genetic markers associated with the disease.

Chai X, Dage JL, and Citron M

Constitutive Secretion of Tau Protein by an Unconventional Mechanism

Neurobiol Dis 48(3):356-66

Publication Date: June 2, 2012

Product Type: iCell GABANeurons

Summary:

This study was designed to elucidate the mechanism(s) of tau processing and cellular trafficking, the dysregulation of which is a hallmark of Alzheimer’s disease and other tauopathies. iCell Neurons were shown to release a small percentage of intracellular tau by a nonconventional pathway that correlates with tau levels observed in vivo.

Impact:

iCell Neurons provided a biologically relevant human cell model to study the protein tau, which plays an important role in the development of Alzheimer’s disease and other neurodegenerative disorders. iCell Neurons provided significant advantages over other available model systems including transformed cell lines and primary neurons in intact animals.