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September 2012

Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, van der Brug M, Liu Y, Ernst JA, Watts RJ, and Atwal JK

Molecular Mechanisms of Alzheimer’s Disease Protection by the A673T Allele of the Amyloid Precursor Protein

J Biol Chem. 289(45):30990-1000

Publication Date: September 24, 2012

Summary:

MyCell Neurons were used to investigate the impact of SNPs in the amyloid precursor protein as it relates to Alzheimer’s disease (AD) progression.

Impact:

MyCell Neurons, cortical neurons manufactured from Alzheimer’s disease model iPS cell lines for this study, express the AD-related amyloid precursor protein making them useful for studying disease behavior and enabling therapeutics research.

Puppala D, Collis LP, Sun SZ, Bonato V, Chen X, Anson B, Pletcher M, Fermini B, and Engle SJ

Comparative Gene Expression Profiling in Human Induced Pluripotent Stem Cell-derived Cardiocytes and Human and Cynomolgus Heart

Toxicol Sci 131(1):292-301

Publication Date: September 14, 2012

Product Type: iCell Cardiomyocytes

Summary:

Gene expression analysis of iCell Cardiomyocytes over a period of 42 days in culture post-thaw and comparison to human fetal and adult cardiac tissue as well as non-human primate cardiac tissue. iCell Cardiomyocytes contractility exhibited functional and pharmacological correlation with myocytes isolated from adult non-human primate heart tissue.

Impact:

This study demonstrated that iCell Cardiomyocytes exhibit genomic signatures similar to adult human heart cells and functional characteristics that correlate with non-human primate heart tissue and thus represent a relevant human model to assess cardiac function.

Sirenko O, Critteden C, Callamaras N, Hesley J, Chen YW, Funes C, Rusyn I, Anson B, and Cromwell EF

Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPS Cells

J Biomol Screen 18(1):39-53

Publication Date: September 12, 2012

Product Type: iCell Cardiomyocytes

Summary:

The FLIPR Tetra High Throughput Cellular Screening System was used to assess cardiac cell physiology and the effects of small molecules on iCell Cardiomyocytes function.

Impact:

This study demonstrated that iCell Cardiomyocytes can be used to assess the effects of small molecules on cardiac function using a high throughput screening platform commonly used in pharmaceutical drug safety and efficacy testing.