Publications

October 2013

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, and Rusyn I

Assessment of Beating Parameters in Human Induced Pluripotent Stem Cells Enables Quantitative In Vitro Screening for Cardiotoxicity

Toxicol Appl Pharmacol 273(3):500-07

Publication Date: October 1, 2013

Product Type: iCell Cardiomyocytes

Summary:

High-throughput protein-based assays were developed with iCell Cardiomyocytes as a system to induce and ameliorate hypertrophy.

Impact:

This research demonstrates the practicality and utility of utilizing relevant native human biology in disease modeling and high throughput screens for drug discovery.

/* ----------------------------------------- */ /* View slug: relevanssi-search-form - start */ /* ----------------------------------------- */ .spinner { margin: 100px auto 0; width: 100px; text-align: center; } .spinner > div { width: 12px; height: 12px; background-color: #fff; background: #6E9934; border-radius: 100%; display: inline-block; -webkit-animation: sk-bouncedelay 1.7s infinite ease-in-out both; animation: sk-bouncedelay 1.7s infinite ease-in-out both; margin-right: 5px; } .spinner .spinner__item1 { -webkit-animation-delay: -0.60s; animation-delay: -0.60s; } .spinner .spinner__item2 { -webkit-animation-delay: -0.40s; animation-delay: -0.40s; } .spinner .spinner__item3 { -webkit-animation-delay: -0.20s; animation-delay: -0.20s; } @-webkit-keyframes sk-bouncedelay { 0%, 80%, 100% { -webkit-transform: scale(0); transform: scale(0); opacity: 0; } 40% { -webkit-transform: scale(1); transform: scale(1); opacity: 1; } } @keyframes sk-bouncedelay { 0%, 80%, 100% { -webkit-transform: scale(0); transform: scale(0); opacity: 0; } 40% { -webkit-transform: scale(1); transform: scale(1); opacity: 1; } } .cdi_search_string_loading { background-image: url('/assets/dots.gif'); background-repeat: no-repeat; background-position: center center; } .gsc-control { width: 300px; } .gsc-control div { position: static; } .gsc-control-cse, .gsc-control-cse .gsc-table-result { width: 100%; font-family: Lato, sans-serif; font-size: 15px; line-height: 1.2em; color: #333333; } .gsc-control-cse div { position: static; } /* control inputs * .gsc-search-box : the container that hosts the text input area * .gsc-input : the text input area * .gsc-keeper : the save link below savable results */ .gsc-search-box { font-size: 20px !important; margin-top : 0; margin-right : 0; margin-bottom : 4px; margin-left : 0; width: 100%; } /* * This table contains the input element as well as the search button * Note that the search button column is fixed width, designed to hold the * button div's background image */ table.gsc-search-box { border-style : none; border-width : 0; border-spacing : 0 0; width : 100%; margin-bottom : 2px; } table.gsc-search-box td { vertical-align : middle; } table.gsc-search-box td.gsc-input { padding-right : 12px; } td.gsc-search-button { width : 1%; } input.gsc-search-button { margin-left : 2px; } .gsc-search-box-tools .gsc-clear-button { position: absolute !important; left: -9999px !important; display: none !important; } .gsc-results-close-btn { background-image: url("//www.google.com/images/nav_logo114.png"); background-repeat: no-repeat; background-position: -140px -230px; float: right; display: none; opacity: 0; height: 12px; width: 12px; position: absolute !important; top: 20px; right: 20px; cursor: pointer; } .gsc-results-close-btn-visible { display: block; opacity: 1; } .gsc-results-wrapper-nooverlay { } .gsc-results-wrapper-overlay { border: none; margin: auto; border-radius: 1px; overflow-y: scroll; overflow-x:hidden;; height: 80%; -webkit-box-shadow: 0px 3px 10px rgba(34, 25, 25, 0.4); -moz-box-shadow: 0px 3px 10px rgba(34, 25, 25, 0.4); -ms-box-shadow: 0px 3px 10px rgba(34, 25, 25, 0.4); -o-box-shadow: 0px 3px 10px rgba(34, 25, 25, 0.4); box-shadow: 0px 3px 10px rgba(34, 25, 25, 0.4); border-collapse: separate; background: white; padding: 30px; width: 70%; position: fixed !important; top: 5%; left: 12%; opacity: 0; z-index: 100002; visibility: hidden; -webkit-transition: all 0.25s linear; -moz-transition: all 0.25s linear; -ms-transition: all 0.25s linear; -o-transition: all 0.25s linear; transition: all 0.25s linear; /* For IE 8 */ -ms-filter: "progid:DXImageTransform.Microsoft.Shadow(Strength=7, Direction=135, Color='#888888')"; /* For IE 5.5 - 7 */ filter: progid:DXImageTransform.Microsoft.Shadow(Strength=7, Direction=135, Color='#888888'); } .gsc-results-wrapper-visible { opacity: 1 !important; visibility: visible !important; } .gsc-modal-background-image { position: fixed !important; top: 0px; left: 0px; height: 130%; width: 100%; z-index: 100001; background-color: white; opacity: 0; -ms-filter:"alpha(opacity=0)"; filter: alpha(opacity=0); display: none; -webkit-transition: all 0.25s linear; -moz-transition: all 0.25s linear; -ms-transition: all 0.25s linear; -o-transition: all 0.25s linear; transition: all 0.25s linear; } .gsc-modal-background-image-visible { opacity: 0.8; -ms-filter:"alpha(opacity=80)"; filter: alpha(opacity=80); display: block; } .gsc-overflow-hidden { overflow: hidden; } /* * Given that this is sitting in a variable width tabel cell, the idea is * for it to consume the entire cell. The adjacent cell contains the search * button and that is a fixed width cell. */ input.gsc-input { padding: 1px 6px; border: 1px solid #DDD; width: 99%; } /* the results for each section * .gsc-resultsbox-{visible,invisible} : a complete-collection of results including headers * .gsc-results : the collection of results for a given searcher * .gsc-result : a generic result within the control. each result has this class, as well as .gsc-xxxResult where xxx is web, image, local, blog, etc. */ .gsc-resultsbox-visible { display : block; } .gsc-resultsbox-invisible { display : none; } .gsc-results { padding-bottom: 2px; width : 99%; } .gsc-result { margin-bottom: 10px; } .gsc-result .gs-title { height: 1.4em; overflow: hidden; } .gsc-wrapper { position : relative; display : block; } /* Added so elements inside a result are properly cleared by the container. */ .gsc-webResult:after { content: "."; display: block; height: 0; clear: both; visibility: hidden; } .gsc-webResult { zoom: 1; /* IE-specific hack to get the layout clearing right. */ } /* Wrapper for a result. */ .gsc-webResult .gsc-result { margin: 0; padding: .5em 0; border-bottom: 1px solid #ebebeb; } .gsc-above-wrapper-area { border-bottom: 1px solid #E9E9E9; padding: 5px 0 5px 0; } .gsc-above-wrapper-area-invisible { display: none; } .gsc-above-wrapper-area-container { width: 100%; } .gsc-result-info { text-align: left; color: #676767; font-size: 13px; padding-left: 8px; margin: 10px 0 10px 0; } .gsc-result-info-container { text-align: left; } .gsc-result-info-invisible { display: none; } .gsc-control-cse .gs-spelling, .gsc-control-cse .gs-result .gs-title, .gsc-control-cse .gs-result .gs-title * { font-size: 17px; color: #6F983B; } .gsc-control-cse .gs-spelling:hover, .gsc-control-cse .gs-result .gs-title:hover, .gsc-control-cse .gs-result .gs-title:hover { color: #ff9c08; } .gsc-control-cse .gs-result .gs-spelling-original { font-size: 16px; color: #343434; } .gs-result a { cursor: pointer; } .gsc-loading-fade .gsc-result-info, .gsc-loading-fade .gsc-loading-resultsRoot, .gsc-loading-resultsRoot, /* customized root */ .gsc-loading-fade .gsc-loading-refinementsArea, .gsc-loading-fade .gsc-adBlock, .gsc-loading-fade .gsc-adBlockVertical, .gsc-loading-fade .gsc-adBlockNoHeight { -ms-filter:"progid:DXImageTransform.Microsoft.Alpha(Opacity=33.3)"; filter: alpha(opacity=33.3); opacity: 0.333; } /* * Cross-browser implementation of the "display: inline-block" CSS property. * See http://www.w3.org/TR/CSS21/visuren.html#propdef-display for details. */ /* Gecko hack */ html>body .gsc-inline-block { display: -moz-inline-box; display: inline-block; } /* Default rule */ .gsc-inline-block { position: relative; display: inline-block; } /* Pre-IE7 IE hack */ * html .gsc-inline-block { display: inline; } /* IE7-only hack */ *:first-child+html .gsc-inline-block { display: inline; } /** * Minimalist theme * */ /* Search form */ .cse form.gsc-search-box, form.gsc-search-box { padding: 8px 4px 2px 6px; margin-bottom: 6px; } /** * Table cell containing the search input. * 12 pixels added to account for the horizontal padding on the input. */ .cse table.gsc-search-box td.gsc-input, table.gsc-search-box td.gsc-input { padding-right: 12px; } .cse .gsc-search-box, .gsc-search-box { border-collapse: collapse; } /* Search input */ .cse input.gsc-input, input.gsc-input { font-family: inherit; border: 1px solid #BBB; padding: 3px 6px; width: 99%; font-size: 16px; } /* Search button */ .cse input.gsc-search-button, input.gsc-search-button { font-family: inherit; font-size: 11px; color: #fff; font-weight: bold; padding: 0 8px; height: 27px; min-width: 54px; background: #333333; border: 1px solid #000; border-radius: 2px; -moz-border-radius: 2px; -webkit-border-radius: 2px; } .cse .gsc-resultsHeader, .gsc-resultsHeader { margin: 0; border: block; } /* Wrapper for all results */ .cse .gsc-results, .gsc-results { width: 100%; margin-top: 1em; } /* Uber-wrapper for a result. Add padding to elements within a result block */ .cse .gs-result div.gs-title, div.gs-title, .cse .gs-result .gs-snippet, .gs-result .gs-snippet, .cse .gs-result .gs-visibleUrl, .gs-result .gs-visibleUrl, .cse .gs-spelling, .gs-spelling { padding: 0; } /* Font size */ .cse .gs-result .gs-snippet, .gs-result .gs-snippet, .cse .gs-spelling-original, .gs-spelling-original { font-size: 14px; line-height: 18px; } /* Inner wrapper for a result */ .cse .gsc-webResult.gsc-result, .gsc-webResult.gsc-result, .gsc-imageResult-classic, .gsc-imageResult-column { padding: 0 0 0 .5em; margin-bottom: 1px; } /* Pagination container centered */ .cse .gsc-cursor-box, .gsc-cursor-box { border-top: 1px dotted; border-color: #333333; padding: .5em 0 0 .5em; text-align: left; } /* Selected pagination */ .cse .gsc-results .gsc-cursor-page.gsc-cursor-current-page, .gsc-results .gsc-cursor-page.gsc-cursor-current-page { color: #fff; background-color: #333333; text-shadow: 0 1px 1px #000; padding: 0 5px; } body .cse .gsc-webResult.gsc-result, body .gsc-webResult.gsc-result, body .gsc-imageResult-classic, body .gsc-imageResult-column { margin-bottom: 0 !important; padding: 10px 0 !important; } #cdi_search_string::-ms-clear { display: none; } /* ----------------------------------------- */ /* View slug: relevanssi-search-form - end */ /* ----------------------------------------- */

Resources

Publications

October 2013