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November 2013

Sirenko O, Hesley J, Rusyn I, and Cromwell EF

High-content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell-derived Cells

Assay Drug Dev Technol 12(1):43-54

Publication Date: November 14, 2013

Product Type: iCell Hepatocytes

Summary:

iCell Hepatocytes were employed in the screening of a panel of 208 known hepatotoxic and 30 safe compounds by high content analysis for multiple toxic endpoint readouts.

Impact:

The predictive power of the iCell Hepatocytes in assessing compound hepatotoxicity suggests their utility as in vitro assay models for toxicity screening and understanding potential hepatotoxic effects early in the drug development process.