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June 2014

Alhebshi AH, Odawara A, Gotoh M, and Suzuki I

Thymoquinone Protects Cultured Hippocampal and Human Induced Pluripotent Stem Cells-derived Neurons against α-synuclein-induced Synapse Damage

Neurosci Lett 570:126-31

Publication Date: June 6, 2014

Product Type: iCell GABANeurons

Summary:

Synapse density, synaptic vesicle recycling and electrical activity were assessed in iCell Neurons before and after treatment with α-synuclein and thymoquinone (TQ). iCell Neurons exhibited toxicity to α-synuclein, which was reduced upon treatment with TQ.

Impact:

Neuroprotection against synapse damage associated with Parkinson’s disease was demonstrated in iCell Neurons, providing evidence that these cells are a relevant system to discover potential therapeutics for neurodegenerative diseases.