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February 2015

Ware BR, Berger DR, Khetani SR

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

Tox Sci 145(2):252-62

Publication Date: February 24, 2015

Product Type: iCell Hepatocytes

Summary:

iCell Hepatocytes were cultured in micropatterned islands and co-cultured with mouse fibroblasts to achieve more functionally mature phenotypes including CYP450s (basal and induced), maturity markers (gene expression), and toxin sensitivity.

Impact:

This research highlights the application of iCell Hepatocytes in more complex (organotypic) culture environments and suggests that appropriate culture conditions and signaling mechanisms lead to more mature iCell Hepatocytes.

Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN

Human iPSC-derived Hepatocyte-like Cells Support Plasmodium Liver-stage Infection In Vitro

Stem Cell Reports 4(3):348-359

Publication Date: February 7, 2015

Product Type: iCell Hepatocytes

Summary:

iCell Hepatocytes were employed as a model for malaria parasite infection. Cells were infected with Plasmodium falciparum and and Plasmodium vivax species.

Impact:

The study demonstrates the application of iCell Hepatocytes for infectious disease research enabling malaria research for parasitic life cycle modeling as well as drug discovery efforts.