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November 2011

Jonsson MK, Wang QD, and Becker B

Impedance-based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-derived Cardiomyocytes

Assay Drug Dev Technol 9(6):589-99

Publication Date: November 15, 2011

Product Type: iCell Cardiomyocytes

Summary:

A series of reference compounds were used to demonstrate the use of iCell Cardiomyocytes with the xCELLigence RTCA Cardio System to detect compound effects on cardiac beat frequency and arrhythmias over an assay period of several days.

Impact:

iCell Cardiomyocytes exhibit electrophysiological characteristics similar to native human cardiomyocytes and showed appropriate response to known toxic drug compounds using a cell analysis platform commonly used in the pharmaceutical industry.