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August 2011

Cohen JD, Babiarz JE, Abrams RM, Guo L, Kameoka S, Chiao E, Taunton J, and Kolaja KL

Use of Human Stem Cell-derived Cardiomyocytes to Examine Sunitinib Mediated Cardiotoxicity and Electrophysiological Alterations

Toxicol Appl Pharmacol 257(1):74-83

Publication Date: August 27, 2011

Product Type: iCell Cardiomyocytes


Elucidation of the molecular mechanisms of sunitinib-induced cardiotoxicity using iCell Cardiomyocytes revealed, contrary to previous data using rodent models, that AMPK and RSK do not play a significant role.


This study illustrates the limitations of non-human model systems and the benefit and importance of using a human cell-based model system to detect and study human cardiotoxicity.