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June 2013

Grose C, Yu X, Cohrs RJ, Carpenter JE, Bowlin JL, and Gilden D

Aberrant Virion Assembly and Limited Glycoprotein C Production in Varicella-Zoster Virus-infected Neurons

J Virol 87(17):9643-8

Publication Date: June 26, 2013

Product Type: iCell GABANeurons


An iCell Neurons in vitro model of varicella zoster virus (VZV) infection developed by Yu, et al. (2013) was used in a subsequent study to determine whether diminished production of virion components and/or final assembly of complete virions play a role in limiting productive virus infection.


Primary VZV infection typically produces varicella (chickenpox), after which the virus becomes latent. Reactivation of the virus produces zoster (shingles), which is a more serious disease characterized by chronic pain and other neurological problems. iCell Neurons are used to model VZV infection and better define the molecular underpinnings of the virus-host relationship.