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January 2014

Dage JL, Colvin EM, Fouillet A, Langron E, Roell WC, Li J, Mathur SX, Mogg AJ, Schmitt MG, Felder CC, Merchant KM, Isaac J, Broad LM, Sher E, and Ursu D

Pharmacological Characterisation of Ligand- and Voltage-gated Ion Channels Expressed in Human iPSC-derived Forebrain Neurons

Psychopharmacology (Berl) 231(6):1105-24

Publication Date: January 7, 2014

Product Type: iCell GABANeurons

Summary:

Gene expression analysis and functional characterization (using FLIPR) of the ion channels (Ca and Na) and receptors (AMPA, NMDA, and GAB) involved in synaptic physiology were performed on iCell Neurons.

Impact:

This study demonstrated that iCell Neurons show higher correlation with the prefrontal cortex and they exhibit functional ionotropic glutamate receptors (AMPA and NMDA) and GABAA receptors. iCell Neurons are a good cellular model of a forebrain human neuron population that can be used both as a control or host of genetic mutations in genetic neurological disease studies (ASD).

Odawara A, Saitoh Y, Alhebshi AH, Gotoh M, and Suzuki I

Long-term Electrophysiological Activity and Pharmacological Response of a Human Induced Pluripotent Stem Cell-derived Neuron and Astrocyte Co-culture

Biochem Biophys Res Commun 443(4):1176-81

Publication Date: January 7, 2014

Product Type: iCell GABANeurons

Summary:

iCell Neurons were co-cultured with rat primary astrocytes to study the effects of a co-culture environment on the longevity, spontaneous firing activity and drug response on the neurons as measured by MEA.

Impact:

iCell Neurons were maintained in culture with the rat astrocytes for an extend period of time (>120 days) and they were able to maintain long-term spontaneous firing that can be modulated with synapse antagonists drugs and detect synchronicity.