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October 2014

Scherf JM, Hu XS, Tepp WH, Ichtchenko K, Johnson EA, Pellett S

Analysis of Gene Expression in Induced Pluripotent Stem Cell-Derived Human Neurons Exposed to Botulinum Neurotoxin A Subtype 1 and a Type A Atoxic Derivative

PLoS One 9(10):e111238

Publication Date: October 22, 2014

Product Type: iCell GABANeurons

Summary:

iCell Neurons were exposed to BoNT and an inactive BoNT derivative to analyze the BoNTs effects on gene expression. Significant transcriptional changes were observed at 14 days post intoxication, specifically in genes related to Ca2+ channel signaling and neurite sprouting.

Impact:

An inactive BoNT derivative has been proposed as a general delivery vehicle to target compounds to neurons. iCell Neurons provided a human model to assess the effects of BoNT and variants to investigate this delivery method.