How do you test the electrophysiology of your cardiomyocytes?

How do you test the electrophysiology of your cardiomyocytes?


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We have demonstrated both evoked and spontaneous action potentials. In addition, Ma et al. (2011) performed an in-depth characterization of iCell® Cardiomyocytes. Electrophysiology can be assessed by a variety of endpoints (e.g. patch clamp, MEA). iCell Cardiomyocytes respond appropriately to known compounds, such as mexiletine (sodium channel antagonist), nifedipine (calcium channel antagonist), dofetilide (potassium channel antagonist), and isoproterenol (beta adrenergic agonist).

Reference:

  1. Ma et al. (2011) High Purity Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Electrophysiological Properties of Action Potentials and Ionic Currents